ASSOCIATION BETWEEN CLOZAPINE RESPONSE AND ALLELIC VARIATION IN 5HT(2A) RECEPTOR GENE

Authors
ARRANZ M COLLIER D SODHI M BALL D ROBERTS G PRICE J SHAM P KERWIN R
Citation
M. Arranz et al., ASSOCIATION BETWEEN CLOZAPINE RESPONSE AND ALLELIC VARIATION IN 5HT(2A) RECEPTOR GENE, Lancet, 346(8970), 1995, pp. 281-282
Citations number
6
Categorie Soggetti
Medicine, General & Internal
Journal title
Lancet → ACNP
ISSN journal
01406736
Volume
346
Issue
8970
Year of publication
1995
Pages
281 - 282
Database
ISI
SICI code
0140-6736(1995)346:8970<281:ABCRAA>2.0.ZU;2-9
Abstract
We report allelic association between a polymorphism (T102C) within th e coding region of the 5-HT2A gene (HTR2A, 13q14-21) and response to c lozapine in schizophrenic patients. Homozygosity for the C102 allele w as more frequent (30/57, 53%) among patients who did not respond to cl ozapine than in those who responded (23/92, 25%). This finding is evid ence that allelic variation of genes which encode neurotransmitter rec eptors can influence clinical response to antipsychotic drugs.