Wh. Farthing et J. Shirani, CORONARY-ARTERY INTIMAL HYPERPLASIA, OCCLUSIVE PLATELET THROMBUS, ANDFATAL MYOCARDIAL-INFARCTION IN AN INTRAVENOUS COCAINE USER, Cardiovascular pathology, 4(3), 1995, pp. 215-219
A 38-year-old man died of an acute inferoposterior myocardial infarcti
on, shortly after intravenous injection of cocaine. At necropsy, diffu
se intimal hyperplasia and an occlusive platelet thrombus involved the
left main, left anterior descending, and the left circumflex coronary
arteries. The possible relation of these morphologic findings to the
effects of cocaine on platelet and coronary vascular function are disc
ussed and the relevant literature is reviewed.