LIPOPROTEIN PROFILE IN BREAST-CANCER WOMEN - EFFECT OF TAMOXIFEN TREATMENT

Electrophoretic lipoprotein analyses were performed in 51 patients on tamoxifen and compared with those obtained from 33 newly diagnosed bre ast cancer patients and with data from the group of healthy women. A s tatistically significant lower rate of dyslipoproteinemia has been dem onstrated in tamoxifen group in comparison with untreated patients; 23 .5% vs. 54.5% (p < 0.01). Comparing the results of the latter group wi th normal subjects there was a significantly higher frequency of dysli poproteinemia in untreated patients, 54.5% vs. 28.9% (p < 0.05). Our f indings confirmed an estrogen-like influence of tamoxifen on lipoprote in profile in postmenopausal breast cancer patients.