EVALUATION OF THE ANTICANCER PROPERTY OF A NEW ALPHA-METHYLENE-GAMMA-LACTONE DERIVATIVE OF PHTHALIMIDE

The anticancer property of a new alpha-methylene-gamma-lactone derivat ive of phthalimide (2, NSC 640168) was evaluated in two murine ascitic tumors namely Ehrlich ascites carcinoma (EAC) and sarcoma-180 (S-180) by in vivo screenings and in a battery of human tumor cell lines by i n vitro screening. It was found that the compound has exhibited margin al to moderate in vivo activity in EAC and S-180, respectively, and si gnificant in vitro cytotoxicity in SF-268, a human CNS tumor cell line . The compound, however, has not reached the criteria of significant a nti-HIV activity.