Lg. Miller, A COMPARATIVE-EVALUATION OF ORAL-CONTRACEPTIVE USE AND ASSOCIATED COMPLIANCE ISSUES IN A RURAL-POPULATION, Clinical therapeutics, 17(3), 1995, pp. 541-551
One hundred thirty-three patients were enrolled in a study designed to
evaluate and compare oral contraceptive use in three rural communitie
s. The patients averaged 31 years old (range, 13 to 49 years); 92% wer
e white, 4.5% Hispanic, and 3% Native American. Genora(R), Ortho-Novum
(R), and Triphasil(R) were the most frequently prescribed oral contrac
eptives. Triphasic oral contraceptives accounted for one third (n = 64
) of 203 prescriptions, and conventional monophasic preparations accou
nted for two thirds. Twenty percent (n = 26) of the patients studied w
ere noncompliant. The most frequent causes of noncompliance cited were
cost and inconvenience. However, generic alternatives were requested
in only 43% of the cases for which generic equivalents were available.
Less-expensive alternatives (eg, generic products, medroxyprogesteron
e acetate injection) should be advocated to deter patient noncomplianc
e because of cost issues. Drug interactions and adverse effects were n
ot reported in our patient population and thus did not contribute to n
oncompliance.