SHIGELLA-FLEXNERI ADHERENCE TO AND MULTIPLICATION IN COXSACKIE B1 VIRUS-INFECTED HEP-2 CELLS

Authors
MODALSLI KR BUKHOLM G HOLBERGPETERSEN M DEGRE M
Citation
Kr. Modalsli et al., SHIGELLA-FLEXNERI ADHERENCE TO AND MULTIPLICATION IN COXSACKIE B1 VIRUS-INFECTED HEP-2 CELLS, APMIS. Acta pathologica, microbiologica et immunologica Scandinavica, 103(4), 1995, pp. 254-260
Citations number
13
Categorie Soggetti
Pathology,Microbiology,Immunology
Journal title
APMIS. Acta pathologica, microbiologica et immunologica Scandinavica → ACNP
ISSN journal
09034641
Volume
103
Issue
4
Year of publication
1995
Pages
254 - 260
Database
ISI
SICI code
0903-4641(1995)103:4<254:SATAMI>2.0.ZU;2-J
Abstract
Coxsackie B1 virus infection enhances the susceptibility of in vitro c ultured HEp-2 cells to invasiveness by Shigella flexneri. We have stud ied the effect of viral infection on two phases of the invasiveness. O nly a minor part was mediated by enhanced bacterial adherence to the c ells, and the intracellular multiplication was unaffected by the virus . Enhanced adherence was not dependent on the presence of the gene pro duct of the 140 Md virulence associated plasmid. Our data indicate tha t enhanced invasiveness induced by viral infection is mediated by an e ffect on other phases of the invasiveness.