The Human Genome Project will produce information permitting increasin
g opportunities to prevent genetically transmitted harms, most of whic
h will be compatible with a life worth living through avoiding concept
ion or terminating a pregnancy. Failure to prevent these harms when it
is possible for parents to do so without substantial burdens or costs
to themselves or others are what I call ''wrongful handicaps'' Derek
Parfit has developed a systematic difficulty for any such cases being
wrongs - when the harm could be prevented only by preventing the exist
ence of the individual who would have a worthwhile life even with the
handicap, then bringing him into existence with the handicap does not
make him worse off and so does not wrong him. I argue that a non ''per
son-affecting'' principle requiring the avoidance of suffering and lim
ited opportunity correctly accounts for cases of wrongful handicaps wi
thout requiring that the individuals with the handicap have been made
worse off and therefore wronged. It is an advantage, not a difficulty,
of this account that it does not imply that the person with the handi
cap has been wronged or is a victim with a special moral complaint.