PEPTIDE-UNIT ASSEMBLING USING S-ALKYLATION - A HIGHLY DENATURATION RESISTANT PROTEIN WAS OBTAINED

Authors
FUTAKI S ISHIKAWA T NIWA M KITAGAWA K YAGAMI T
Citation
S. Futaki et al., PEPTIDE-UNIT ASSEMBLING USING S-ALKYLATION - A HIGHLY DENATURATION RESISTANT PROTEIN WAS OBTAINED, Tetrahedron letters, 36(29), 1995, pp. 5203-5206
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
29
Year of publication
1995
Pages
5203 - 5206
Database
ISI
SICI code
0040-4039(1995)36:29<5203:PAUS-A>2.0.ZU;2-B
Abstract
Four peptide-units were assembled selectively through S-alkylation to afford a four-helix-bundle protein consisting of 81 residues. Introduc tion of a disulfide to the protein as an additional inter-unit cross-l inking made the molecule highly resistant against chaotropic and therm al denaturation.