WHITE-LIGHT HOLE-BURNING OF TO-PRO-3 BOUND TO OLIGOMERIC DNA

Authors
MILANOVICH N HAYES JM SMALL GJ
Citation
N. Milanovich et al., WHITE-LIGHT HOLE-BURNING OF TO-PRO-3 BOUND TO OLIGOMERIC DNA, Molecular crystals and liquid crystals science and technology. Section A, Molecular crystals and liquid crystals, 291, 1996, pp. 147-154
Citations number
6
Categorie Soggetti
Crystallography
Journal title
Molecular crystals and liquid crystals science and technology. Section A, Molecular crystals and liquid crystals → ACNP
ISSN journal
1058725X
Volume
291
Year of publication
1996
Pages
147 - 154
Database
ISI
SICI code
1058-725X(1996)291:<147:WHOTBT>2.0.ZU;2-L
Abstract
Binding of the dye TO-PRO-3 iodide to alternating GC and AT oligomers of DNA is investigated by absorption and hole burning spectroscopies. This dye is one of a series extensively used for nucleic acid staining . In addition to narrow laser induced holes, the dye/oligomer complexe s also exhibit white light induced hole burning. These holes are indic ative of a dye/DNA binding mode in addition to the previously identifi ed externally bound and intercalative modes. Possible structures of th is mode are considered.