MURIHEXOCIN-A AND MURIHEXOCIN-B, 2 NOVEL MONO-THF ACETOGENINS WITH 6 HYDROXYLS, FROM ANNONA-MURICATA (ANNONACEAE)

Two novel bioactive acetogenins, murihexocins A (1) and B (2), were is olated from the leaves of the sour sop tree, Annona muricata (Annonace ae). 1 and 2 are C-35 mono-tetrahydrofuran (THF) acetogenins having si x hydroxyls, and their structures have been elucidated by spectroscopi c analyses and derivations. No Annonaceous acetogenins having six hydr oxyls or with two vicinal diol groups have been reported previously. 1 and 2 showed significant inhibitory effects among six human tumor cel l lines with interesting selectivities to the prostate (PC-3) and panc reatic (PACA-2) cell lines.