SYNTHESIS OF 3'-O-(2-AMINOETHYL)-2'-DEOXYURIDINES

Authors
ALEEM AAHA LARSEN E PEDERSEN EB NIELSEN C
Citation
Aaha. Aleem et al., SYNTHESIS OF 3'-O-(2-AMINOETHYL)-2'-DEOXYURIDINES, Acta chemica Scandinavica, 49(8), 1995, pp. 609-614
Citations number
23
Categorie Soggetti
Chemistry,Biology
Journal title
Acta chemica Scandinavica → ACNP
ISSN journal
0904213X
Volume
49
Issue
8
Year of publication
1995
Pages
609 - 614
Database
ISI
SICI code
0904-213X(1995)49:8<609:SO3>2.0.ZU;2-D
Abstract
Methyl 2-deoxy-3-O-[2-(formyl amino)ethyl]-5-O-trityl-D-erythro-pentof uranoside (4) was obtained in a 3-O alkylation reaction by treatment w ith 2-chloroethylamine in DMF. Compound 4 afforded or nucleosides as t he main products when condensed with uracils under the Vorbruggen cond itions. The nucleosides were deblocked by treatment with 80% acetic ac id and subsequently with sodium methoxide in methanol.