FAST-ATOM-BOMBARDMENT MASS-SPECTROMETRY COUPLED WITH COLLISION-INDUCED DISSOCIATION OF A HYDANTOIN SERIES FOR FRAGMENTATION STUDIES

Authors
HENCZI M WEAVER DF
Citation
M. Henczi et Df. Weaver, FAST-ATOM-BOMBARDMENT MASS-SPECTROMETRY COUPLED WITH COLLISION-INDUCED DISSOCIATION OF A HYDANTOIN SERIES FOR FRAGMENTATION STUDIES, Rapid communications in mass spectrometry, 9(9), 1995, pp. 804-808
Citations number
18
Categorie Soggetti
Spectroscopy,"Chemistry Analytical
Journal title
Rapid communications in mass spectrometry → ACNP
ISSN journal
09514198
Volume
9
Issue
9
Year of publication
1995
Pages
804 - 808
Database
ISI
SICI code
0951-4198(1995)9:9<804:FMCWC>2.0.ZU;2-X
Abstract
Phenytoin is one of the most widely employed anticonvulsant drugs in t he world. Because this drug has several side effects, an exhaustive st ructure-toxicity study is needed. To find an easy and cost-effective w ay to monitor phenytoin In metabolism and toxicity studies, 18 phenyto in derivatives were synthesized and analysed by fast-atom bombardment tandem mass spectrometry.