MULTIVARIATE GENETIC-ANALYSIS OF DATA OF COMPLEX INVESTIGATION OF PREDISPOSITION TO SCHIZOPHRENIA

49 families of schizophrenics (49 probands and their 106 first-degree relatives) were studied by means of psychological methods, EEG and com puted tomography. Multivariate genetic analysis were performed to asse ss genetic and environmental components of parameter phenotypic varian ce and relations beetween the parameters and liability to schizophreni a, including formation of discriminant functions for classification of individuals into high risk and normal groups and estimation of the fu nctions heritability. Besides, correlations between parameters of neur omorphological, neurophysiological and psychological levels were calcu lated. The heritability of most EEG and CT parameters were between 41 and 98%. Among psychological variables only mediated and logic memory seem to be under sufficient genetic control (relatively 62 and 42%). D iscriminant functions derived from psychological and EEG parameters, a llow to differentiate correctly individuals into high risk and normal groups in 76 - 88% cases. Results of correlational analysis of psychol ogical and biological variables suggest that there are both system and separete genetically determined abnormalities related to different le vels of pathogenesis.