Vi. Trubnikov et al., MULTIVARIATE GENETIC-ANALYSIS OF DATA OF COMPLEX INVESTIGATION OF PREDISPOSITION TO SCHIZOPHRENIA, Zurnal nevropatologii i psihiatrii im. S.S. Korsakova, 95(2), 1995, pp. 50-56
49 families of schizophrenics (49 probands and their 106 first-degree
relatives) were studied by means of psychological methods, EEG and com
puted tomography. Multivariate genetic analysis were performed to asse
ss genetic and environmental components of parameter phenotypic varian
ce and relations beetween the parameters and liability to schizophreni
a, including formation of discriminant functions for classification of
individuals into high risk and normal groups and estimation of the fu
nctions heritability. Besides, correlations between parameters of neur
omorphological, neurophysiological and psychological levels were calcu
lated. The heritability of most EEG and CT parameters were between 41
and 98%. Among psychological variables only mediated and logic memory
seem to be under sufficient genetic control (relatively 62 and 42%). D
iscriminant functions derived from psychological and EEG parameters, a
llow to differentiate correctly individuals into high risk and normal
groups in 76 - 88% cases. Results of correlational analysis of psychol
ogical and biological variables suggest that there are both system and
separete genetically determined abnormalities related to different le
vels of pathogenesis.