S. Tsuji et al., GASTRIC-ULCER HEALING AND BASIC FIBROBLAST GROWTH-FACTOR - EFFECTS OFLANSOPRAZOLE AND FAMOTIDINE, Journal of clinical gastroenterology, 20, 1995, pp. 1-4
We examined the effects of lansoprazole and famotidine on gastric basi
c fibroblast growth factor (bFGF) levels and ulcer healing in patients
with gastric ulcer. Sixteen patients with active gastric ulcer were d
ivided into two groups and received treatment with lansoprazole 30 mg/
day or famotidine 40 mg/day. They were examined endoscopically at 2, 4
, and 8 weeks to measure gastric bFGF levels at the ulcer margin and t
o assess ulcer healing. Helicobacter pylori infection was determined b
y a rapid urease test. The two groups were comparable with regard to a
ge, male:female ratio, H. pylori infection rates, and bFGF levels. Dur
ing treatment, bFGF levels did not change significantly in the famotid
ine group, whereas they increased by a factor of 2.2 to 2.6 in the lan
soprazole group. Cumulative healing rates were also significantly lowe
r in the famotidine group than in the lansoprazole group. These result
s indicate that lansoprazole increases tissue bFGF levels and promotes
gastric ulcer healing in humans.