THE EFFECT OF LANSOPRAZOLE TREATMENT ON THE HEALING AND RELAPSE OF PEPTIC-ULCER AND SERUM LEVELS OF IGG ANTI-HELICOBACTER PYLORI ANTIBODY

In the present study, the effects of short-term treatment with lansopr azole on healing and recurrence of peptic ulcer were investigated. Com plete healing (change to the S-2 stage) after 3 or 4 weeks of treatmen t with lansoprazole was observed in 9.9% of gastric ulcers and 38.3% o f duodenal ulcers. Complete healing was observed after 3 or 4 weeks of treatment with lansoprazole in gastric ulcers and was significantly r elated to the serum titer of IgG anti-Helicobacter pylori antibodies. This was not the case in duodenal ulcers. Complete healing after 6 or 8 weeks of treatment with lansoprazole was not dependent on serum leve ls of IgG anti-H. pylori antibodies. Short-term treatment by lansopraz ole did not affect serum levels of IgG anti-H. pylori antibodies immed iately after the end of lansoprazole treatment, but significantly redu ced serum levels of IgG anti-H. pylori antibodies were found 9 months after treatment.