ASYMMETRY OF MOTION VEP IN INFANTILE STRABISMUS AND IN CENTRAL VESTIBULAR-NYSTAGMUS

Norcia el al. [1] found a nasal-temporal asymmetry of visually evoked potentials (VEP) elicited by motion stimuli in patients with infantile strabismus. Patients with infantile serabismus typically present with an asymmetry of the monocular optokinetic nystagmus (OKN). We here ad dress the question whether the asymmetry of the motion VEP indicates a sensory defect in the afferent visual pathway that could explain the OKN asymmetry. We recorded the VEP to a horizontally. oscillating vert ical sinusoidal grating in 20 patients with infantile strabismus (esot ropia, asymmetry of the monocular optokinetic nystagmus, latent (sic)) and in 10 normal controls. No asymmetry occurred in the 10 controls. Eight of the 20 patients with infantile strabismus showed a clear diff erence between the VEPs evoked by back and forth movements with a mirr or-like asymmetry between the two eyes (phase shift 180 +/- 20 degrees ). However, there was no significant correlation between the degree of VEP and OKN asymmetries. Therefore, we assume that the VEP asymmetry does not reflect the primary cause of the OKN asymmetry. Rather, the O KN asymmetry may be due to a sensory-motor defect in the efferent subc ortical pathway, and the VEP asymmetry could be an epiphenomenon. Some of the VEP asymmetry may be a consequence of the latent nystagmus typ ically released under monocular stimulation, leading to adaptation of the afferent retino-cortical pathway. This suggestion is supported by a marked VEP asymmetry that we found in two patients with an acquired central vestibular nystagmus, an abnormality most likely not combined with a primary defect of the retino-cortical pathway.