ASSOCIATION OF REDUCED PR-AC INTERVAL WITH VENTRICULAR EARLY POTENTIALS IN DILATED CARDIOMYOPATHY

We studied 31 patients with dilated cardiomyopathy, correlating mitral valve cusp motion with the continuous wave Doppler signal of mitral r egurgitation and the signal averaged electrocardiogram (EGG). Sixteen patients had a B point (early partial closure) on the mitral echogram and 15 did not. Fifteen normal cases were used as controls. The durati on of ventricular early potentials (< 40 mu V) was measured on the sig nal averaged ECG of the QRS complex. The PR interval was increased in patients with a B point (190 (33) ms vs. 145 (16) ms in normal, P < 0. 01) and PR-AC interval was reduced (25 (71) ms vs. 65 (11) ms in norma l, P < 0.05). The B point itself was effectively synchronous with the onset of low velocity early systolic mitral regurgitation, and followe d the Q wave of the succeeding beat by 20 ms or less. Early low veloci ty on mitral regurgitation was not present in patients without a B poi nt. The duration of early potentials was greatly increased in patients with a B point (43 (26) ms) compared both to those without (17 (20) m s, P < 0.01) and to normals (12 (7) ms, P < 0.01) and their duration c orrelated with B-C interval (r = 0.6, P < 0.02). We conclude that a B point on the mitral echogram in patients with left ventricular disease is due to early systolic low velocity mitral regurgitation which itse lf results from an abnormal pattern of left ventricular activation, pr obably bilateral bundle branch block. Once established, this low veloc ity jet delays complete mitral valve closure.