LOCALIZATION OF PURA, THE GENE ENCODING THE SEQUENCE-SPECIFIC SINGLE-STRANDED-DNA-BINDING PROTEIN PUR-ALPHA, TO CHROMOSOME BAND 5Q31

Authors
MA ZW PEJOVIC T NAJFELD V WARD DC JOHNSON EM
Citation
Zw. Ma et al., LOCALIZATION OF PURA, THE GENE ENCODING THE SEQUENCE-SPECIFIC SINGLE-STRANDED-DNA-BINDING PROTEIN PUR-ALPHA, TO CHROMOSOME BAND 5Q31, Cytogenetics and cell genetics, 71(1), 1995, pp. 64-67
Citations number
13
Categorie Soggetti
Cell Biology","Genetics & Heredity
Journal title
Cytogenetics and cell genetics → ACNP
ISSN journal
03010171
Volume
71
Issue
1
Year of publication
1995
Pages
64 - 67
Database
ISI
SICI code
0301-0171(1995)71:1<64:LOPTGE>2.0.ZU;2-0
Abstract
Pura (PurA) is a sequence-specific single-stranded-DNA-binding protein implicated in control of both DNA replication and transcription, We h ave localized the Pum gene (PURA) to human chromosome band 5q31 by flu orescence in situ hybridization with a 16-kb genomic probe together wi th hybridization of a cDNA probe to blots of DNA from human-hamster ce ll lines containing individual human chromosomes. Sequences with homol ogy to the PURA locus are I also present at 6q14. The 5q31 locus is fr equently deleted in myelogenous leukemias and other cancers.