IMMEDIATE AND DELAYED TOLERANCE OF IOHEXOL AND IOXAGLATE IN LOWER-LIMB PHLEBOGRAPHY - A DOUBLE-BLIND COMPARATIVE-STUDY IN HUMANS

Rationale and Objectives. We compared the tolerance and efficacy of io hexol-300, a nonionic low-osmolar monomer, with those of ioxaglate-320 , an ionic low-osmolar dimer, in lower limb phlebography. Methods. One hundred twenty inpatients were randomly divided into two groups in th is double-blind comparative study. Two hundred milliliters of contrast medium (100 mi per leg) was injected intravenously. The immediate tol erance was classified as discomfort (i,e., sensation of warmth, pain, coldness related to the injection) and adverse events occurring up to 1 hr after administration. Delayed tolerance was followed up to 8 days after the examination. The main parameter was immediate adverse event s. Image quality was assessed by a radiologist using a visual analog s cale. Results. The number of immediate adverse events was significantl y higher in the ioxaglate group (P < .02). The more frequent events we re digestive disorders and skin rashes; 13 of these events were report ed in the ioxaglate group, but none were reported in the iohexol group (P < .001). The other parameters were not significantly different in the two groups. Conclusion. We found a similar efficacy and a better t olerance of iohexol-300 than ioxaglate-320 in lower limb phlebography.