Malaria, according to the World Health Organization, is one of the mos
t serious and complex health problems facing humanity in the 20th cent
ury. In the past, climatic changes have greatly affected its geography
. Its seriousness and complexity are therefore likely to be compounded
by an anthropogenic greenhouse effect. The Malaria Potential Occurren
ce Zone (MOZ) model was designed to calculate first-order estimates of
climate change impacts on malaria. MOZ focuses on the climatic determ
inants of the life cycles of malaria parasites and vectors. It does no
t take epidemiology into account. MOZ predicts receptivity, or potenti
al transmission, rather than actual occurrence. MOZ indicates that the
intensity and the extent of malaria potential transmission significan
tly change under the climate change scenarios generated by five atmosp
heric general circulation models. All five simulations reveal an incre
ase in seasonal malaria at the expense of perennial malaria. This is c
ause for great concern. Indeed, seasonal malaria is most likely to lea
d to epidemics among unprepared or nonimmune populations. Moreover, cl
imate change may trigger massive migrations of environmental refugees.
Such population movements would likely put national and international
health infrastructures under severe stress. Today, malaria is a devel
oping country issue but could spread to higher latitudes. The results
obtained with MOZ suggest that malaria could become a public-health pr
oblem for developed countries within decades.