A methodology is developed to evaluate the response sensitivity of str
uctural systems to variations in their design parameters. The sensitiv
ity is evaluated by considering the global behavior of the system resp
onse when the parameters vary within a bounded region. The design para
meters are characterized by means of baseline values plus fluctuating
components, and the sensitivity of the system is measured in terms of
the global variability of the response with respect to its baseline re
sponse. The methodology is then extended into the context of optimum r
edesign analysis of structural systems. Application of the method is m
ade to a structural system defined by two-dimensional beam-column elem
ents and to a system defined by plate elements. The numerical implemen
tation of the global sensitivity approach is made by means of the fini
te element method. Several analyses are performed and the results are
discussed. Finally, some extensions of the present work are presented.