MULTIPLE ENDOCRINE NEOPLASIA TYPE-1 ACCOMPANIED BY DUODENAL CARCINOID-TUMORS AND HYPERGASTRINEMIA - A FAMILIAL CASE

A 38-year-old female was admitted for investigation of the cause of hy pergastrinemia, hypercalcemia and an elevated plasma parathyroid hormo ne (PTH) level, Her siblings, elder brother and sister who had duodena l carcinoid tumor with hypergastrinemia and parathyroid adenomas, were diagnosed as multiple endocrine neoplasia (MEN) type 1, In the presen t patient, endoscopic examination showed a carcinoid tumor of the duod enum, but examinations by computed tomography (CT) and ultrasonography of the abdomen failed to reveal pancreatic lesions, Serum gastrin lev els of this patient and her siblings improved to the normal level afte r resection of carcinoid tumors. The hypergastrinemia accompanying MEN type 1 in these cases might be due to carcinoid tumor of the duodenum .