We describe a case of multiple polypoid lesions that occurred in the c
olon of a 62-year-old man, Eight of the lesions were demonstrated by b
arium enema, and five mere examined histologically. A small nodule in
the submucosa of the ascending colon was histologically identical to g
ranular cell tumor, characterized by nested growth of large tumor cell
s with ample granular cytoplasm and small round nuclei, Immunohistoche
mically, the cells were positive for S-100, neuron-specific enolase an
d vimentin, and negative for alpha-smooth muscle actin and desmin.