SUCCESSFUL HEMATOPOIETIC RECONSTITUTION WITH GRANULOCYTE-COLONY-STIMULATING FACTOR IN A PATIENT WITH HYPOPLASTIC ACUTE MYELOGENOUS LEUKEMIA

We describe a 68-year-old Japanese male with hypoplastic acute myeloge nous leukemia (AML) who achieved complete hematological reconstitution following granulocyte colony-stimulating factor (G-CSF) administratio n, The patient had pancytopenia and the bone marrow was hypocellular w ith 19 to 36% peroxidase-positive blasts without morphological abnorma lities suggestive of myelodysplasia, After receiving G-CSF as a suppor tive therapy for pneumonia, the blood count became normal and the bone marrow was normocellular with less than 5% of blasts, Without subsequ ent chemotherapy, he relapsed as a form of overt leukemia and died of pneumonia, Chemotherapy may be necessary to maintain remission in hypo plastic AML after hematopoietic reconstitution by G-CSF.