FOCAL NECROTIZING PANNICULITIS AND VASCULAR NECROSIS IN RATS GIVEN SUBCUTANEOUS INJECTIONS OF COCAINE HYDROCHLORIDE

Authors
SCOTT DW MORRELL JI VERNOTICA EM
Citation
Dw. Scott et al., FOCAL NECROTIZING PANNICULITIS AND VASCULAR NECROSIS IN RATS GIVEN SUBCUTANEOUS INJECTIONS OF COCAINE HYDROCHLORIDE, Journal of cutaneous pathology, 24(1), 1997, pp. 25-29
Citations number
26
Categorie Soggetti
Pathology,"Dermatology & Venereal Diseases
Journal title
Journal of cutaneous pathology → ACNP
ISSN journal
03036987
Volume
24
Issue
1
Year of publication
1997
Pages
25 - 29
Database
ISI
SICI code
0303-6987(1997)24:1<25:FNPAVN>2.0.ZU;2-F
Abstract
Subcutaneous injections of cocaine hydrochloride in sterile physiologi cal saline were administered to rats at a dosage of 20 or 40 mg.kg(-1) . Resultant skin lesions included focal areas of alopecia (within 1 to 2 days) which progressed to necrosis (within 2 to 7 days). Histologic ally, the skin lesions were characterized by necrotizing panniculitis and vascular necrosis, with only small numbers of inflammatory cells. The lesions may be ischemic in nature, and associated with cytotoxic p roperties of cocaine. (C) Munksgaard 1997.