THYROID-HORMONE TREATMENT OF DEPRESSION

The use of thyroid hormones in the treatment of depression is reviewed . The studies examining the use of triodothyronine (T-3) alone as well as in combination with antidepressants are discussed. The data sugges t that there is little evidence that Tg alone has antidepressant effic acy but that this hormone may be used to enhance therapeutic effects o f antidepressants in treatment refractory depressed patients. The diff erent theories to explain the antidepressant effects of T-3 are summar ized.