PHYSICAL WITHDRAWAL IN RATS TOLERANT TO DELTA(9)-TETRAHYDROCANNABINOLPRECIPITATED BY A CANNABINOID RECEPTOR ANTAGONIST

Authors
TSOU K PATRICK SL WALKER JM
Citation
K. Tsou et al., PHYSICAL WITHDRAWAL IN RATS TOLERANT TO DELTA(9)-TETRAHYDROCANNABINOLPRECIPITATED BY A CANNABINOID RECEPTOR ANTAGONIST, European journal of pharmacology, 280(3), 1995, pp. 13-15
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
280
Issue
3
Year of publication
1995
Pages
13 - 15
Database
ISI
SICI code
0014-2999(1995)280:3<13:PWIRTT>2.0.ZU;2-O
Abstract
Tolerance to Delta(9)-tetrahydrocannabinol (Delta(9)-THC) was produced in rats by twice daily injections (15 mg/kg i.p.) for 6.5 days. Admin istration of the cannabinoid antagonist SR141716A (i.p. or i.c.v.) ind uced a profound precipitated withdrawal syndrome in Delta(9)-THC-toler ant animals. The syndrome was characterized by a disorganized pattern of constantly changing brief sequences of motor behavior. Autonomic si gns were not evident. THC-tolerant animals that were treated with vehi cle remained quiet throughout the observation period.