The concept that T cells are subdivided into T helper 1 (Th1) and Th2
subsets was recently extended to suggest that Th1 cells contribute to
the pathogenesis of several organ-specific autoimmune diseases, wherea
s Th2 cells inhibit disease development. Here, Sylvie Trembleau and co
lleagues examine the role of interleukin 12 (IL-12), a Key cytokine gu
iding the development of Th1 cells, in the induction of autoimmune dis
eases, and discuss potential immunointervention strategies based on ad
ministration of IL-12 antagonists.