Mj. Morgan et al., THE DEVELOPMENTAL REGULATION OF A NOVEL MUSCLE LIM-PROTEIN, Biochemical and biophysical research communications, 212(3), 1995, pp. 840-846
Using a cDNA clone derived from a human muscle library we have identif
ied a novel and highly conserved 2.3kb homologue which is highly expre
ssed in skeletal muscle. The partial sequence contains at least three
LIM domains and shows greatest homology with the group of LIM-proteins
associated with the cytoskeleton and focal adhesion plaques which inc
lude zyxin and paxillin. This homologue is maximally expressed in diff
erentiated ovine primary muscle cultures. It is also expressed in the
ovine fetus from at least 50 days of gestation and is increasingly upr
egulated from 120 days of gestation to 8 weeks after birth after which
it declines. This period corresponds to the period of greatest muscle
fibre hypertrophy and suggests a role for this homologue in either th
e elaboration of muscle fibre matrix anchorage or the regulation of mu
scle fibre hypertrophy itself. (C) 1995 Academic Press, Inc.