TEICOPLANIN ADMINISTRATION IN BURN PATIEN TS - INFLUENCE OF GRAVITY PARAMETERS

The aim of this retrospective study was to evaluate if Unit Burn Stand ard (UBS) and Time of Administration After Injury (TAAI) could be pred ictive factors for the determination of a suitable dose regimen. Data were obtained from the medical records of each patient treated between 1991 and 1993. Patients with impaired renal fonction were excluded. T hirty patients were included in the study. They were divided (a) in tw o groups : group 1 for UBS < 75 (n = 19) and group 2 for UBS > 75 (n = 11) and (b) in 3 groups : group A for TAAI < 10 (n = 10), group B for 11 < TAAI < 21 (n = 13) and group C for TAAI > 21 (n = 7). The charac teristics of patients were similar in all groups : age, serum creatini ne, serum albumin. The mean daily loading dose was 18.9 +/- 5.5 mg/kg during 3.6 +/- 1.7 days and the mean daily maintenance dose was 16.8 /- 7.1 mg/kg. The mean duration of treatment was 13.5 +/- 7.4 days. Th ere was no significant difference between the groups with regard to an y of the parameters investigated. The daily dose necessary to obtain t herapeutic serum levels (trough level = 15-25 mg/l) was not significan tly different in all groups. UBS and TAAI seem not to be predictive fa ctors for the determination of the dose regimen in burn patients.