The authors present a rare case of myocardial infarction in a fifty-ei
ght-year-old man without significant coronary artery stenosis apparent
on the emergency coronary angiogram. However, a second angiogram two
days later revealed a total occlusion of the left anterior descending
artery. Intracoronary thrombolytic therapy was performed with a succes
sful outcome. The patient was subsequently readmitted with an acute my
ocardial infarction, and the coronary angiogram again failed to demons
trate significant stenosis. Thereafter, the patient's left ventricular
function deteriorated progressively, with the occurrence of another m
yocardial infarction and frequent bouts of symptoms related to congest
ive heart failure. He died of ischemic cardiomyopathy about seven year
s later. Findings including an autopsy report showed that myocardial i
schemia was involved in the pathogenesis of what initially appeared to
be primary dilated cardiomyopathy, based on emergency angiograms.