EVOLUTION OF ACQUIRED SEVERE APLASTIC-ANE MIA TO A MYELODYSPLASTIC SYNDROME AND ACUTE-LEUKEMIA

Survival of patients with severe acquired aplastic anemia has improved dramatically during the past decade mainly due to the use of new trea tments. The long-term follow-up of these patients has allowed to obser ve an increased incidence of late malignant hematological complication s such as myelodysplastic syndromes and leukemia, which raises the que stion wether they are just different forms of presentation of the same disease. We report two cases of severe acquired aplastic anemia with long-time survival, one of them developed a myelodysplastic syndrome a nd the other one a myelodysplastic syndrome followed by an acute leuke mia. We discusse the factors associated with a high risk to develope m yelodysplastic syndrome and acute leukemia, and its repercussions in t herapy.