INDUCIBLE NITRIC-OXIDE SYNTHASE IN THE CENTRAL-NERVOUS-SYSTEM

There is an accumulation of evidence indicating that induction of the calcium-independent isoform of nitric oxide synthase (iNOS) in glial c ells can contribute to nitric oxide-mediated neural-cell damage. Eluci dation of iNOS inducing signals and mechanisms regulating its augmenta tion and suppression may have implications for our understanding of ba sic processes underlying some forms of central nervous system disease.