PHARMACOLOGICAL ACTION OF LITHIUM IN THE PATHOGENESIS OF PSORIASIS

The influence of lithium on psoriasis has been demonstrated by differe nt studies. Lithium can induce a new onset or exacerbate pre-existing psoriasis. Different mechanisms are implicated in the pharmacological mode of action of lithium in relation to the onset of psoriasis. On th e molecular level, it is well established that cAMP plays a key role i n the pathogenesis of lithium-induced psoriasis. Lithium may also affe ct the protein kinase C-inositol-biphosphate pathway by an inhibition of inositol-1-phosphatase, resulting in the alteration of cellular tra nsduction signals. On the cellular level, lithium has a mitogen effect and acts by blocking cellular differentiation. It also exerts a chemo tactic action on neutrophil polymorphonuclear cells.