The life of Filippo Pacini (1812-1883) and his major scientific achiev
ements are outlined. Pacini drew attention to the corpuscles named aft
er him in 1831,when he was a medical student, and had to struggle for
many years to convince the scientific community of the reliability and
importance of his findings. In 1849 Pacini became professor of anatom
y at the University of Florence. Creative scientist, innovative teache
r, well aware that the use of the microscope represented a revolutiona
ry approach, Pacini pursued histological studies until his death. He a
lso first discovered in 1854 (30 years before Robert Koch) the causati
ve agent of cholera, and firmly believed that the disease was contagio
us. Strong-willed, modest, and poor, Pacini received from his colleagu
es more recognition in the obituaries than during his life.