UP-REGULATION OF TRKB MESSENGER-RNA EXPRESSION IN THE RAT STRIATUM AFTER SEIZURES

Citation
T. Salin et al., UP-REGULATION OF TRKB MESSENGER-RNA EXPRESSION IN THE RAT STRIATUM AFTER SEIZURES, Neuroscience letters, 194(3), 1995, pp. 181-184
Citations number
22
Categorie Soggetti
Neurosciences
Journal title
ISSN journal
03043940
Volume
194
Issue
3
Year of publication
1995
Pages
181 - 184
Database
ISI
SICI code
0304-3940(1995)194:3<181:UOTMEI>2.0.ZU;2-Q
Abstract
The present study investigates the expression of a tyrosine kinase rec eptor (trkB), its specific ligands brain-derived neurotrophic factor ( BDNF) and neurotrophin-4 (NT-4) mRNAs in the striatum after seizures. The result showed an increase of trkB mRNA expression, both with and w ithout tyrosine kinase domain, in the caudate-putamen and nucleus accu mbens, but not in the globus pallidus. This increase peaked 3 h after treatment, and returned to normal levels by 12 h. The BDNF and NT-4 mR NAs showed no change at any time. In conclusion, the widespread and ma ssive trkB mRNA induction after abnormal neuronal activity suggests lo cal trophic support for this receptor, and a potential role in basal g anglia diseases involving non-dopaminergic components.