FURTHER EVIDENCE OF A DOSE-RESPONSE THRESHOLD FOR HALOPERIDOL IN PSYCHOSIS

Objective: The authors' goal was to determine whether higher doses of haloperidol improve antipsychotic response. Method: During a 2-week, d ouble-blind, randomized fixed-dose study, 24 psychotic patients were g iven 4, 10, or 40 mg/day of haloperidol. Results: No clinically releva nt difference between groups in favor of the higher antipsychotic dose s could be detected. Conclusions: Doses of 4 mg/day of haloperidol app ear to be as effective as higher doses in the treatment of psychosis.