INTERLEUKIN-6 (IL-6) LEVELS IN THE MONITORING OF SURGICAL TRAUMA - A COMPARISON OF SERUM IL-6 CONCENTRATIONS IN PATIENTS TREATED BY CHOLECYSTECTOMY VIA LAPAROTOMY OR LAPAROSCOPY
M. Maruszynski et Z. Pojda, INTERLEUKIN-6 (IL-6) LEVELS IN THE MONITORING OF SURGICAL TRAUMA - A COMPARISON OF SERUM IL-6 CONCENTRATIONS IN PATIENTS TREATED BY CHOLECYSTECTOMY VIA LAPAROTOMY OR LAPAROSCOPY, Surgical endoscopy, 9(8), 1995, pp. 882-885
Interleukin 6 (IL-6) is involved in the processes of inflammation and
tissue repair. We have been looking for the correlation between IL-6 c
oncentration in patient's serum and the other factors related to the g
ravity of surgical trauma. Out of 25 patients with acute cholecystitis
, 11 were randomly selected for laparoscopic cholecystectomy and the o
ther 14 for open (laparotomic) cholecystectomy. The diagnostic and pro
gnostic factors, age, and duration of disease did not differ significa
ntly in either group. IL-6 serum levels were monitored by using commer
cially available ELISA tests throughout 72 h following the surgery. In
patients who underwent laparoscopy, average IL-6 serum levels were si
gnificantly (up to fourfold) lower than in their laparotomy-treated co
unterparts, and the monitoring of IL-6 serum levels seems to be useful
in the evaluation of the extent of trauma caused by surgery.