PERINATAL RENAL CHANGES ASSOCIATED WITH VESICOURETERAL REFLUX

In an attempt to resolve the question of the relative contributions of hydrodynamic pressure and infection to the pathogenesis of reflux nep hropathy, we studied the pathologic changes in 46 kidneys subjected to vesico-ureteral reflux and obtained at necropsy from 36 patients, all aged less than 4 days. No scarring was seen in any of the kidneys, bu t 11 were hypoplastic and 4 were partly or completely dysplastic. This study supports the view that the pathologic features of reflux nephro pathy are due to post-natal infection rather than to the hydrodynamic effect of reflux.