HYPERKERATOTIC SPICULES AND MONOCLONAL GAMMOPATHY

Hyperkeratotic spicules are a rare disorder that has been associated w ith different types of malignancies. An association with multiple myel oma raises the question of a relation between the monoclonal component and skin manifestations. We describe hyperkeratotic spicules in a 61- year-old man with a monoclonal gammopathy of undetermined significance . Immunofluorescence and immunoelectron microscopic findings demonstra ted the deposition of the monoclonal immunoglobulin at the dermoepider mal junction. Our findings support previous reports that the associati on between hyperkeratotic spicules and monoclonal gammopathy is not fo rtuitous and may be related to particular properties of the monoclonal immunoglobulin.