Sm. Manders et al., THALIDOMIDE-RESISTANT HIV-ASSOCIATED APHTHAE SUCCESSFULLY TREATED WITH GRANULOCYTE-COLONY-STIMULATING FACTOR, Journal of the American Academy of Dermatology, 33(2), 1995, pp. 380-382
Thalidomide has been advocated as the treatment of choice for recalcit
rant aphthae. We describe the case of patient with HIV infection and e
xtensive aphthae whose condition failed to respond to corticosteroids,
cyclosporine, and thalidomide. The patient's course was complicated b
y colonic aphthae. Rapid and sustained resolution was achieved through
treatment with granulocyte colony-stimulating factor, a previously un
reported therapeutic option.