SCALE-UP OF AGITATION FLUIDIZED-BED GRANULATION .2. EFFECTS OF SCALE,AIR-FLOW VELOCITY AND AGITATOR ROTATIONAL SPEED ON GRANULE SIZE, SIZEDISTRIBUTION, DENSITY AND SHAPE

Authors
WATANO S SATO Y MIYANAMI K MURAKAMI T NAGAMI N ITO Y KAMATA T ODA N
Citation
S. Watano et al., SCALE-UP OF AGITATION FLUIDIZED-BED GRANULATION .2. EFFECTS OF SCALE,AIR-FLOW VELOCITY AND AGITATOR ROTATIONAL SPEED ON GRANULE SIZE, SIZEDISTRIBUTION, DENSITY AND SHAPE, Chemical and Pharmaceutical Bulletin, 43(7), 1995, pp. 1217-1220
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
7
Year of publication
1995
Pages
1217 - 1220
Database
ISI
SICI code
0009-2363(1995)43:7<1217:SOAFG.>2.0.ZU;2-Q
Abstract
Scale-up characteristics of agitation fluidized bed granulation using a pharmaceutical standard formulation was described, The effects of sc ale, air flow velocity and agitator rotational speed on granule proper ties such as granule mass median size, size distribution, apparent den sity and shape factor were investigated experimentally, Based on the r esults obtained, the effects of these parameters on granule growth and the mechanism of granule formation in different sized equipment were discussed.