SCALE-UP OF AGITATION FLUIDIZED-BED GRANULATION .3. EFFECTS OF POWDERFEED WEIGHT AND BLADE ANGLE ON GRANULE SIZE, DENSITY AND SHAPE

Authors
WATANO S SATO Y MIYANAMI K ITO Y KAMATA T ODA N
Citation
S. Watano et al., SCALE-UP OF AGITATION FLUIDIZED-BED GRANULATION .3. EFFECTS OF POWDERFEED WEIGHT AND BLADE ANGLE ON GRANULE SIZE, DENSITY AND SHAPE, Chemical and Pharmaceutical Bulletin, 43(7), 1995, pp. 1224-1226
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
7
Year of publication
1995
Pages
1224 - 1226
Database
ISI
SICI code
0009-2363(1995)43:7<1224:SOAFG.>2.0.ZU;2-Q
Abstract
This paper presents the experimental results of a study on the scale-u p characteristics of granule compaction and sphericity in an agitation fluidized bed granulation, A pharmaceutical standard formulation was granulated using agitation fluidized bed of three sizes (vessel diamet er: 125, 230, 500 mm), The effects of powder feed weight and agitator blade angle on the granule properties of size, density and shape were studied, It was found that granules were compressed and made spherical with an increase in agitator blade angle and vessel scale, while they were not influenced by the powder feed ratio.