S. Watano et al., SCALE-UP OF AGITATION FLUIDIZED-BED GRANULATION .4. SCALE-UP THEORY-BASED ON THE KINETIC-ENERGY SIMILARITY, Chemical and Pharmaceutical Bulletin, 43(7), 1995, pp. 1227-1230
The scale-up theory based on kinetic energy similarity was proposed to
elucidate the scale-up characteristics in agitation fluidized bed gra
nulation, In this model, kinetic energy given to granules by agitator
rotation and fluidizing air were taken into consideration, It was foun
d that granule mass median diameter, apparent density and shape factor
can be well expressed by the parameter (R omega/u)(2), which showed t
he ratio of kinetic energy by agitator rotation to that by fluidizing
air, Based on the results obtained, effects of operational variables a
nd scale factor on the granule properties could be explained theoretic
ally and granule growth mechanism in agitation fluidized bed granulati
on was elucidated in detail.