SCALE-UP OF AGITATION FLUIDIZED-BED GRANULATION .4. SCALE-UP THEORY-BASED ON THE KINETIC-ENERGY SIMILARITY

Citation
S. Watano et al., SCALE-UP OF AGITATION FLUIDIZED-BED GRANULATION .4. SCALE-UP THEORY-BASED ON THE KINETIC-ENERGY SIMILARITY, Chemical and Pharmaceutical Bulletin, 43(7), 1995, pp. 1227-1230
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
ISSN journal
00092363
Volume
43
Issue
7
Year of publication
1995
Pages
1227 - 1230
Database
ISI
SICI code
0009-2363(1995)43:7<1227:SOAFG.>2.0.ZU;2-N
Abstract
The scale-up theory based on kinetic energy similarity was proposed to elucidate the scale-up characteristics in agitation fluidized bed gra nulation, In this model, kinetic energy given to granules by agitator rotation and fluidizing air were taken into consideration, It was foun d that granule mass median diameter, apparent density and shape factor can be well expressed by the parameter (R omega/u)(2), which showed t he ratio of kinetic energy by agitator rotation to that by fluidizing air, Based on the results obtained, effects of operational variables a nd scale factor on the granule properties could be explained theoretic ally and granule growth mechanism in agitation fluidized bed granulati on was elucidated in detail.