A NOVEL 16,23-EPOXY-5-BETA-CHOLESTANE GLYCOSIDE WITH POTENT INHIBITORY ACTIVITY ON PROLIFERATION OF HUMAN PERIPHERAL-BLOOD LYMPHOCYTES FROMORNITHOGALUM-SAUNDERSIAE BULBS

Authors
KURODA M MIMAKI Y SASHIDA Y HIRANO T OKA K DOBASHI A
Citation
M. Kuroda et al., A NOVEL 16,23-EPOXY-5-BETA-CHOLESTANE GLYCOSIDE WITH POTENT INHIBITORY ACTIVITY ON PROLIFERATION OF HUMAN PERIPHERAL-BLOOD LYMPHOCYTES FROMORNITHOGALUM-SAUNDERSIAE BULBS, Chemical and Pharmaceutical Bulletin, 43(7), 1995, pp. 1257-1259
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
7
Year of publication
1995
Pages
1257 - 1259
Database
ISI
SICI code
0009-2363(1995)43:7<1257:AN1GWP>2.0.ZU;2-L
Abstract
A novel 16,23-epoxy-5 beta-cholestane triglycoside (1) was isolated fr om the bulbs of Ornithogalum saundersiae (Liliaceae). The structure wa s determined by extensive spectroscopic analysis. The conformation of the E-ring part of 1 was studied through molecular mechanics and molec ular dynamics calculation methods. Compound 1 potently inhibited proli feration of peripheral blood lymphocytes provided from a chronic renal failure patient without causing any cytotoxicity in the lymphocytes a nd HL-60 human leukemia cells.