RELATIONSHIPS BETWEEN PROTEASOMES AND RNA

The 20S proteasome (prosome) is a highly organized multi-protein compl ex with approximate molecular weight of about 700 kDa. Whilst the role of the proteasome in the processing and turnover of cellular proteins is becoming clearer, its relationship with RNA remains obscure. Over the last decade the possibility of association of proteasomes with spe cific RNAs or mRNPs have been particularly controversial. Proteasomes were reported to inhibit translation of viral mRNAs and to be tightly associated with RNase activity. It is possible that proteasomes are al so involved in cellular RNA breakdown and RNA processing like prokaryo tic RNase E.