A general and powerful formalism has been developed for computation of
energy-loss spectra of penetrating charged particles in the presence
of charge exchange. Options on the input side are the cross sections f
or electron capture and loss, transition rates for radiative and nonra
diative spontaneous processes and their associated energy losses or ga
ins, and finally, cross sections for all processes that contribute to
particle stopping but are not associated with charge exchange. The for
malism generates an n x n transfer matrix, where n is the number of st
ates needed for an adequate description of the projectile under consid
eration. This matrix delivers the joint distribution of energy loss an
d exit charge state for a given incident charge state and energy. The
formalism can be used in principle as an alternative for Monte Carlo s
imulation, but until now we have concentrated on direct evaluation of
key experimental parameters related to the energy-loss spectrum integr
ated over all exit charge states, in particular, mean energy loss, str
aggling, and skewness. Generally, valid analytic expressions have been
found for these quantities, each of which can be separated into a sta
tionary term representing charge state equilibrium and a transient dep
ending on the incident charge state. A brief survey is given of curren
t analytic and numerical efforts addressing other experimental paramet
ers.