A RAPID SPECTROFLUOROMETRIC METHOD FOR THE DETERMINATION OF METYROSINE IN FORMULATIONS AND BIOLOGICAL-FLUIDS

Authors
HEFNAWY MM ALY FA BELAL F
Citation
Mm. Hefnawy et al., A RAPID SPECTROFLUOROMETRIC METHOD FOR THE DETERMINATION OF METYROSINE IN FORMULATIONS AND BIOLOGICAL-FLUIDS, Analytical letters, 28(10), 1995, pp. 1811-1818
Citations number
6
Categorie Soggetti
Chemistry Analytical
Journal title
Analytical letters → ACNP
ISSN journal
00032719
Volume
28
Issue
10
Year of publication
1995
Pages
1811 - 1818
Database
ISI
SICI code
0003-2719(1995)28:10<1811:ARSMFT>2.0.ZU;2-U
Abstract
A simple, rapid and sensitive fluorimetric method is described for the determination of metyrosine in bulk, in dosage forms and in biologica l fluids. The method is based on measuring the fluorescence produced i n isopropanol. The fluorescence is measured at 610 nm after excitation at 282 nm. The fluorescence intensity is a linear function of metyros ine concentration over the range of 0.2-3.2 mu g ml(-1) with a detecti on limit of 0.08 mu g ml(-1). The advantages of the proposed method ov er methods were discussed.