ANALYSIS OF B-10 BY PIGE WITH FACTOR ANALYTICAL GAMMA-RAY PEAK IDENTIFICATION

Studying the biodistribution of boronated compounds for B neutron capt ure therapy (BNCT) requires the accurate detection of low levels of bo ron (B-10) in biological samples. Proton induced gamma-ray emission an alysis (PIGE) of B-10 was found to be viable in a study of low density lipoprotein (LDL), in tissue and blood samples. However, the method i s sensitive to Na present in the samples and can therefore not be used for accurate measurements of B-10 concentrations below 5 ppm in sampl es containing Na. PIGE can be considered to be an appropriate referenc e method for chemical B analysis. The factor analytical method present ed here is the most objective way to separate Na and B peaks from each other, and the factorizing method can be applied in different forms o f spectral analysis.