PATTERNS OF LOSS OF HETEROZYGOSITY AT LOCI FROM CHROMOSOME ARM 13Q SUGGEST A POSSIBLE INVOLVEMENT OF BRCA2 IN SPORADIC BREAST-TUMORS

Authors
KERANGUEVEN F ALLIONE F NOGUCHI T ADELAIDE J SOBOL H JACQUEMIER J BIRNBAUM D
Citation
F. Kerangueven et al., PATTERNS OF LOSS OF HETEROZYGOSITY AT LOCI FROM CHROMOSOME ARM 13Q SUGGEST A POSSIBLE INVOLVEMENT OF BRCA2 IN SPORADIC BREAST-TUMORS, Genes, chromosomes & cancer, 13(4), 1995, pp. 291-294
Citations number
28
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Genes, chromosomes & cancer → ACNP
ISSN journal
10452257
Volume
13
Issue
4
Year of publication
1995
Pages
291 - 294
Database
ISI
SICI code
1045-2257(1995)13:4<291:POLOHA>2.0.ZU;2-J
Abstract
Loss of heterozygosity (LOH) at loci from chromosome 13 is frequently observed in breast cancer. Chromosome 13 contains at least two cancer genes, the well-characterized RB1 gene located at 13q14 and the breast cancer-susceptibility gene, BRCA2, recently localized to 13q12. To in vestigate the possible involvement of BRCA2 in sporadic breast tumors, we looked at LOH at eight microsatellite (CA)'' markers distributed a long chromosome 13 in a panel of 59 primary breast carcinomas. We show that some LOH does not include the RB1 locus and is associated with t he BRCA2 gene region.